🦠 Made up my own memory tricks — Amp(G)atekeeper, Amp(D)umpster, Amp(R)epressor — to understand AmpC mechanics. Learnt Serratia has 2 recyclers (AmpD + AmiD2) making derepression harder, and E. coli lacks AmpR so AmpC stays silent! 🙌
📊 Dipping my toes into financial statements — income, balance sheet & cash flow. Still don’t fully get it, but slowly piecing together the story these numbers tell. Warren Buffett makes it look easy 😅 Baby steps! 🌱
Exploring pip/tazo PTA for Pseudomonas using popPK simulation. Key finds: 30-min infusions fall short of 90% PTA at MIC 16; prolonged infusion helps, but neutropenic fever population sees the biggest drop in PTA. ~46% of susceptible PsA isolates carry blaOXA-2 — tazobactam matters more than I thought
🧪 Diving into PK/PD for the first time — simulating ceftriaxone with mrgsolve in R. Free drug levels were… surprisingly high? Even pushed it to q48h dosing out of curiosity and the results left me with more questions than answers 🤔📈
Learnt major carbapenemase genes (KPC, NDM, OXA) using NCBI isolate data and molecular dynamics. Includes gene frequency trends, co-resistance patterns, and MM/PBSA binding comparisons of avibactam with KPC vs NDM to illustrate mechanistic differences 🧬