#IDWeek2026 Posts/Tweets Analysis

860 posts 📉 a new low for #IDWeek2026 on social media! But the learning didn’t stop 🧠 Waning measles antibodies in infants, oral care to cut NV-HAP 🪥, MedGemma for TB 🫁, and more! Thank you all who have contributed!

Porin Loss/Mutation and Efflux Pump Overexpression - Mechanism of Antimicrobial Resistance in Gram-Negative Bacteria

Porins let drugs in, efflux pumps kick them out — alone, neither does much damage. Real resistance in Gram-negatives needs porin loss, efflux overexpression, and β-lactamases working together. Plus a surprising twist about Pseudomonas and ertapenem that challenges conventional teaching.

ROC, Paper, Scissor, Shoe

📊 Working through ROC-AUC from scratch, then poking at its blind spots — low prevalence, calibration, and finally Decision Curve Analysis. Mostly notes to myself on what I learned (and got confused by) along the way. 🤔📈

Cross-Validation From Scratch and a Surprise at n=100

Textbooks say LOOCV has the lowest bias but highest variance compared to 10 and 5-fold. Coded a K-Fold CV from scratch for learning to test that on simulated data 🔍📊 — and at n=1000 it holds up. At n=100? Not so much. 🤔

Learning Amino Acids Part 1: Non-Polar Amino Acids, Rodrigues Rotation, and Lennard-Jones Potential

🧬 Back to basics! Learning non-polar amino acids, what zwitterions actually are, and dipping into the applied math — Rodrigues rotation and Lennard-Jones potential. Slowly building toward optimal phi/psi!