Textbooks say LOOCV has the lowest bias but highest variance compared to 10 and 5-fold. Coded a K-Fold CV from scratch for learning to test that on simulated data 🔍📊 — and at n=1000 it holds up. At n=100? Not so much. 🤔
🧬 Back to basics! Learning non-polar amino acids, what zwitterions actually are, and dipping into the applied math — Rodrigues rotation and Lennard-Jones potential. Slowly building toward optimal phi/psi!
Exploring the CovR/S two-component system in Group A Strep 🧫 — from genome annotation with Bakta & BaktFold, to AlphaFold confidence metrics, and a first attempt at protein docking with Haddock3. Learning as we go! 🙌
A note to myself on survival analysis — KM curves, log-rank tests & Cox models 🧮 If I wrote it the way I understood it, maybe I’ll actually remember it 🤞
Dipping my toes into quantum computing 🌊 — circuits, gates, superposition. Still very much a beginner, but hands-on experiments with qiskit + R’s reticulate made it click a little more. Baby steps!